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FLASH GENE

Symbol

SH3GL3

contributors: mct - updated : 01-06-2022

HGNC name	SH3-domain GRB2-like 3
HGNC id	10832

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	186.48 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003027 9 splicing 1693 NP_003018 39.3 347 - 2020 32193381 EEN-B2-L1 NM_001301108 9 splicing 1686 NP_001288037 31.6 278 - 2020 32193381 EEN-B2-L2 NM_001301109 12 splicing 2015 NP_001288038 40.2 355 - 2020 32193381 EEN-B2-L3 EEN-B2-L4 - splicing 2738 - 340 - 2020 32193381 NM_001324183 10 - 1844 NP_001311112 - 355 - 2020 32193381 NM_001324184 11 - 2175 NP_001311113 - 312 - 2020 32193381 NM_001324185 10 - 1837 NP_001311114 - 278 - 2020 32193381 NM_001324182 10 - 1863 NM_001324182 - 360 - 2020 32193381 NM_001324186 10 - 2024 NP_001311115 - 312 - 2020 32193381 NM_001324187 9 - 1737 NP_001311116 - 278 - 2020 32193381

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Nervous brain diencephalon hypothalamus   highly   brain limbic system hippocampus dentate gyrus   Reproductive male system testis         male system prostate     moderately Respiratory lung

cells

System Cell Pubmed Species Stage Rna symbol Nervous Purkinje cell Nervous pyramidal cell

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	eye, lens, retina foveal, macular, eye, anterior segment, RPE, choroid

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one SH3 domain
	one BAR domain

HOMOLOGY

interspecies	ortholog to murine Sh3d2c2
	homolog to rattus Sh3d2c1
	homolog to Drosophila endoA
	homolog to C.elegans T04D1.3

intraspecies	homolog to Src-homology 3 domain GRB2-like gene 3
	paralog to SH3GL1

Homologene

FAMILY

endophilin family

CATEGORY

adaptor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endosome

basic FUNCTION	playing a regulatory role in synaptic vesicle recycling
	promoting formation of insoluble polyglutamine-containing aggregates
	promotes growth and migration of colon cancers, by linking membrane dynamics to GTPase regulation
	acts as a potent tumor suppressor in lung cancer progression

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

text	central nervous system development

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	binding to synaptojanin,dynamin 1 and HDEX1P (huntingtin exon 1 protein)
	SH3GL2, SH3GL1, and SH3GL3, are recruited to the necks of endocytic clathrin-coated pits by its curvature sensitive BAR domain and binds both dynamin and synaptojanin
	SH3GL3 stimulates cell migration by binding the Rac GEF TIAM1 leading to activation of small GTPase
	SH3GL3 associates with ALCAM-containing early endocytic carriers and physically interacts with the cargo
	acts as a novel tumor suppressor in glioblastoma tumorigenesis by inhibiting STAT3 signaling

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	have a potential to serve as diagnostic and prognostic biomarker of lung cancer
Therapy target

ANIMAL & CELL MODELS