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FLASH GENE

Symbol

FGF10

contributors: mct - updated : 31-01-2016

HGNC name	fibroblast growth factor 10
HGNC id	3666

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

ALSG , LADD3

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in &8764;10p100 of breast cancers and increased levels of FGF10 are highly correlated with proliferation rate of breast cancer cell lines and cancer cell invasion

Susceptibility

to chronic obstructive pulmonary disease (COPD) to lethal lung maldevelopment, including acinar dysplasia (AcDys), congenital alveolar dysplasia (CAD)spectrum

Variant & Polymorphism other	FGF10 haploinsufficiency affects lung function measures providing a model for a dosage sensitive effect of FGF10 in the development of COPD
	SNVs or CNVs involving FGF10 loci in our subjects with lethal lung maldevelopment, including acinar dysplasia (AcDys), congenital alveolar dysplasia (CAD)spectrum

Candidate gene	candidate gene in patients with anorectal malformations and exstrophy of the cloaca
Marker	FGF10 and FGF17 could be prognostic biomarkers for survivals of acute myeloid leukemia patients
Therapy target
	System Type Disorder Pubmed cardiovascular atheroma   may be a promising agent for treatment of ischemic stroke cardiovascular aquired   potential target for cardiac repair

ANIMAL & CELL MODELS

	defective terminal differentiation and hypoplasia of
	epidermis in Fgf10(-/-) mouse
	overexpression of Fgf10 in adult mice promotes cardiomyocyte but not cardiac fibroblast cell-cycle re-entry