Symbol
| FGF10
| contributors: mct - updated : 31-01-2016
|
HGNC name
| fibroblast growth factor 10
|
HGNC id
| 3666
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
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tumoral
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|  
| --over
|  
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in &8764;10p100 of breast cancers and increased levels of FGF10 are highly correlated with proliferation rate of breast cancer cell lines and cancer cell invasion | |
Susceptibility
|
to chronic obstructive pulmonary disease (COPD) to lethal lung maldevelopment, including acinar dysplasia (AcDys), congenital alveolar dysplasia (CAD)spectrum |
Variant & Polymorphism
other
| FGF10 haploinsufficiency affects lung function measures providing a model for a dosage sensitive effect of FGF10 in the development of COPD |
|
SNVs or CNVs involving FGF10 loci in our subjects with lethal lung maldevelopment, including acinar dysplasia (AcDys), congenital alveolar dysplasia (CAD)spectrum |
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Candidate gene
| candidate gene in patients with anorectal malformations and exstrophy of the cloaca |
Marker
| FGF10 and FGF17 could be prognostic biomarkers for survivals of acute myeloid leukemia patients |
Therapy target
|
System | Type | Disorder | Pubmed |
cardiovascular | atheroma | | |
may be a promising agent for treatment of ischemic stroke | cardiovascular | aquired | | |
potential target for cardiac repair |
| |
| defective terminal differentiation and hypoplasia of | |
epidermis in Fgf10(-/-) mouse |
|
overexpression of Fgf10 in adult mice promotes cardiomyocyte but not cardiac fibroblast cell-cycle re-entry |