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FLASH GENE
Symbol FGF10 contributors: mct - updated : 31-01-2016
HGNC name fibroblast growth factor 10
HGNC id 3666
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • hydrophobic N terminal domain (40AA) serving as a signal sequence
  • a FGF domain
  • two N-glycosylation sites
  • an heparin binding site and several phosphorylation sites
  • conjugated GlycoP , RiboP
    HOMOLOGY
    interspecies homolog to rattus Fgf10 (100.00 pc)
    homolog to murine Fgf10 (94.69 pc)
    intraspecies paralog to FGF7
    Homologene
    FAMILY
  • heparin-binding growth factors family
  • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • initiation and growth of the limb bud
  • triggering FGF8 expression in ectoderm and SHH expression in mesoderm
  • regulate keratinocyte proliferation and differentiation by binding to the tyrosine kinase KGF receptor (FGFR2)
  • stimulating wound healing
  • essential regulator of lung and limb formation
  • role in prostatic development, morphogenesis and epithelial proliferation, adipogenesis
  • promoting the proliferation of embryonic pancreatic epithelial cells
  • regulates the morphogenesis of the hepatopancreatic duct and intestinal tube
  • regulating G1 cyclins and CDKs
  • promotes invasion and outgrowth of trophoblasts and it increases SPRY2 expression, which attenuates trophoblast sprouting
  • implicated in control of neurogenesis
  • controls the patterning of the tracheal cartilage rings via SHH
  • potentially regulating Meckel cartilage formation during early mandibular morphogenesis by controlling the cell differentiation in the lateral area of the mandibular process
  • FGF3 and FGF10 are not required for specification of cardiovascular progenitors, but rather for their normal developmental coordination
  • likely functional network involving BARX2, FGF10 and MMPs that plays an essential role in regulating branching morphogenesis of the ocular glands
  • may contribute to human preantral follicle development.
  • FGF8 and FGF10 promotes the proliferation of the cardiac progenitor cells that form the arterial pole of the heart
  • FGF10 and FGF3 secreted from the forming neurohypophysis exert direct guidance effects on hypothalamic neurosecretory axons
  • prevents the differentiation of distal epithelial progenitors into SOX2-expressing airway epithelial cells
  • FGF7 and FGF10 are involved in the proliferation of ameloblastoma cells through the MAPK pathway
  • SDC4 participates likely in amelogenesis, and FGF10 may modulate dental epithelial cell behaviors through the regulation of SDC4 expression
  • regulates regional cardiomyocyte proliferation in the fetal heart, and triggers cell-cycle re-entry of adult cardiomyocytes
  • neuroprotective function of FGF10 against ischemic neuronal injury
  • dual role for FGF10 in cochlear development, to regulate outgrowth of the duct and subsequently as a bidirectional signal that sequentially specifies Reissner membrane and outer sulcus non-sensory domains
  • involvement in breast tumorigenesis
  • role of a TBX4-FGF10-FGFR2 epithelial-mesenchymal signaling in lung organogenesis
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    nucleotide, transcription, regulation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling signal transduction
  • FGF10/FGFR2b signaling is essential for cardiac fibroblast development and growth of the myocardium
  • DLX5-FGF10 signaling cascade controls cranial neural crest and myoblast interaction during oropharyngeal patterning and development
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand for FGFR2 receptor
  • CEBP in adipocytes
  • upregulating Na, K-ATPase via thr MAPK pathway
  • interacting with FGFR2B for palate development(coordinated epithelial-mesenchymal interactions are essential during the initial stages of palate development and require an FGF-SHH signaling network)
  • interacting with FGFBP1
  • key role for FGF3, and a secondary role for FGF10, in WNT8A expression
  • interacting with cortactin (involved in keratinocyte migration promoted by both FGF7 and FGF10)
  • ELAVL1 bind and control the FGF10 and TBX4 mRNAs
  • BARX2 and FGF10 cooperate in the regulation of MMPs)
  • ISL1 directly regulates FGF10 transcription during human cardiac outflow formation
  • TBX4 and TBX5 interact with FGF10 during the process of lung growth and branching but not during tracheal/bronchial cartilage development
  • inhibition of FGF10 by inflammatory signaling involves the NFKB1-dependent interactions between RELA, SP3, and the FGF10 promoter
  • PBX1 directly binds to the FGF10 promoter and cooperates with MEIS and HOX proteins to transcriptionally activate FGF10
  • ETV1 and EWSR1 transactivate FGF10 directly and cooperatively in response to apical ectodermal ridge (AER)-FGFs
  • LHX9 expression overlaps with FGF10 expression in the developing limb bud mesenchyme
  • glycoprotein that specifically binds to FGFR2 to control signaling pathways including cell differentiation, proliferation, and apoptosis
  • TBX4, TBX5 are both upstream regulators of FGF10 and RSPO2, which drive the outgrowth of all four limb buds
  • cell & other
    REGULATION
    activated by GATA3 that directly activates FGF10 in the early inner ear, and does so through a single binding site
    ASSOCIATED DISORDERS
    corresponding disease(s) ALSG , LADD3
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in &8764;10p100 of breast cancers and increased levels of FGF10 are highly correlated with proliferation rate of breast cancer cell lines and cancer cell invasion
    Susceptibility
  • to chronic obstructive pulmonary disease (COPD)
  • to lethal lung maldevelopment, including acinar dysplasia (AcDys), congenital alveolar dysplasia (CAD)spectrum
  • Variant & Polymorphism other
  • FGF10 haploinsufficiency affects lung function measures providing a model for a dosage sensitive effect of FGF10 in the development of COPD
  • SNVs or CNVs involving FGF10 loci in our subjects with lethal lung maldevelopment, including acinar dysplasia (AcDys), congenital alveolar dysplasia (CAD)spectrum
  • Candidate gene candidate gene in patients with anorectal malformations and exstrophy of the cloaca
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascularatheroma 
    may be a promising agent for treatment of ischemic stroke
    cardiovascularaquired 
    potential target for cardiac repair
    ANIMAL & CELL MODELS
  • defective terminal differentiation and hypoplasia of
  • epidermis in Fgf10(-/-) mouse
  • overexpression of Fgf10 in adult mice promotes cardiomyocyte but not cardiac fibroblast cell-cycle re-entry