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FLASH GENE
Symbol FGF10 contributors: mct - updated : 31-01-2016
HGNC name fibroblast growth factor 10
HGNC id 3666
ASSOCIATED DISORDERS
corresponding disease(s) ALSG , LADD3
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in &8764;10p100 of breast cancers and increased levels of FGF10 are highly correlated with proliferation rate of breast cancer cell lines and cancer cell invasion
Susceptibility
  • to chronic obstructive pulmonary disease (COPD)
  • to lethal lung maldevelopment, including acinar dysplasia (AcDys), congenital alveolar dysplasia (CAD)spectrum
  • Variant & Polymorphism other
  • FGF10 haploinsufficiency affects lung function measures providing a model for a dosage sensitive effect of FGF10 in the development of COPD
  • SNVs or CNVs involving FGF10 loci in our subjects with lethal lung maldevelopment, including acinar dysplasia (AcDys), congenital alveolar dysplasia (CAD)spectrum
  • Candidate gene candidate gene in patients with anorectal malformations and exstrophy of the cloaca
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascularatheroma 
    may be a promising agent for treatment of ischemic stroke
    cardiovascularaquired 
    potential target for cardiac repair
    ANIMAL & CELL MODELS
  • defective terminal differentiation and hypoplasia of
  • epidermis in Fgf10(-/-) mouse
  • overexpression of Fgf10 in adult mice promotes cardiomyocyte but not cardiac fibroblast cell-cycle re-entry