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FLASH GENE

Symbol

RPS4X

contributors: mct - updated : 11-03-2020

HGNC name	ribosomal protein S4, X-linked
HGNC id	10424

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	escaping inactivation
text	escaping inactivation
STRUCTURE	5.21 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

Map	cen - DXS1275 - ED1 - MLLT7 - DXS983 - DXS8107 - DXS8052 - [IL2RG ,GJB1 ,TAF1 ] - PHKA1 - CDX4 - DXS1005E ,XIST ,RPSAP14 - DXS8037 ,DXS8092 ,DXS1221 ,DXS7025E ,DXS1103E ,SLC16A2 ,DXS8060 ,DXS8066 - ATRX ATRX - DXS6980E - qter
Authors	Mumm (98), LaFrenière (93)
Text	[RPS4X ]

RNA

TRANSCRIPTS	type	messenger

text	X-linked isoform

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001007 7 - 1474 NP_000998 29 263 - 1994 8139551

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node         Urinary bladder

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Muscular myoblast Homo sapiens Skin/Tegument keratinocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a KOW (Kyprides, Ouzounis, Woese) motif

HOMOLOGY

intraspecies

paralog to RPS4Y

Homologene

FAMILY

ribosomal protein S4e family

CATEGORY

structural protein , RNA associated

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,cytosolic,ribosome
	intracellular,nucleus,nucleoplasm

basic FUNCTION	40S ribosomal protein S4 involved in protein biosynthesis, development, cell proliferation, regulation of cell cycle
	involved in cellular translation and proliferation
	higher RPS4X expression in both myoblasts and myotubes from women, together with lower methylation levels in the promoter
	escapes X inactivation

CELLULAR PROCESS	cell cycle
	cell life, proliferation/growth
	protein, translation/synthesis

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in gastric cancer tumoral     --over   associated with a lower risk of death and later disease progression in serous epithelial ovarian cancer constitutional     --over   RPS4X exhibited the highest expression in XXY ( tumoral     --low   is associated with poor disease-specific and recurrence-free survival in bladder cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	RPS4X is an independent prognostic factor in patients with serous epithelial ovarian cancer
Therapy target

ANIMAL & CELL MODELS