Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CPA1 contributors: mct - updated : 02-05-2014
HGNC name carboxypeptidase A1 (pancreatic)
HGNC id 2296
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a leader sequence
  • an activation peptide
  • a carbopeptidase moiety with a zinc binding site
  • a 16-AA secretory signal peptide and a 94-AA propeptide
    • conjugated MetalloP
    mono polymer monomer
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Cpa
    Homologene
    FAMILY zinc carboxypeptidase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • cleaving substrates with C terminal hydrophobic residues
  • pancreatic metalloprotease that hydrolyze C-terminal peptide bonds in dietary polypeptide chains
  • CPA1, CPA2 might play a role in the renin-angiotensin system in addition to their functions as digestive enzymes
  • CPA1 and CPA2 act on aromatic and aliphatic amino acid residues that are exposed by the action of chymotrypsins and elastases
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS digestion
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    ions zinc Zn2+ binding
    protein
  • interacting with ELA2A
  • CTRC is a physiological co-activator of proCPA1 and proCPA2 and is a key regulator of digestive zymogen activation
    • cell & other
    REGULATION
    activated by proteolytic cleavage at the C-terminal end of the propeptide by trypsin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to nonalcoholic chronic pancreatitis
    Variant & Polymorphism other
  • loss-of-function CPA1 variants are strongly associated with nonalcoholic chronic pancreatitis, especially early onset disease (PMId:23955596)
    • Candidate gene
    Marker
  • increased pro-CPA1 and CPA1 levels is a biomarker for the diagnosis of pancreatitis and pancreatic cancer
    • Therapy target
    ANIMAL & CELL MODELS