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FLASH GENE
Symbol UQCRB contributors: mct - updated : 24-11-2020
HGNC name ubiquinol-cytochrome c reductase binding protein
HGNC id 12582
DNA
TYPE functioning gene
STRUCTURE 12.59 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 8459 13.4 111 - 1996 8751380
5 - 8596 - 140 - 1996 8751380
5 - 8573 - 79 - 1996 8751380
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver    
Nervousbrain    
Reproductivemale systemprostate  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Uqcrb
Homologene
FAMILY ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex)
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,inner
intracellular,cytoplasm,organelle,membrane
basic FUNCTION
  • involved in redox-linked proton pumping
  • plays a crucial role in hypoxia-induced angiogenesis via mitochondrial reactive oxygen species (ROS)-mediated signaling
  • potential key roles of UQCRB in angiogenesis and mitochondria-mediated metabolic disorders
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism energetic
    signaling
    mitochondrial respiratory chain
    a component
  • complex III of mitochondrial respiratory chain, oxidative phosphorylation (OXPHOS)
  • component of cytochrome bc1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ubiquinol binding
  • mitochondrial UQCRB positively regulates KDR signaling in Endothelial cells
  • critical role of ELAVL1 in regulating lipid transport and ATP synthesis, by regulating the splicing of APOB mRNA and the translation of UQCRB and NDUFB6
  • cell & other
    REGULATION
    activated by thyroid hormones
    ASSOCIATED DISORDERS
    corresponding disease(s) CMP3D
    related resource MITOP database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    inhibits the cancer stem cell-like properties in glioblastoma cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    UQCRB and its inhibitors could be a new therapeutic target and lead compounds for eliminating cancer stem cells in glioblastoma
    cancerangiogenesis 
    mitochondrial UQCRB modulators are promising antiangiogenic agents
    ANIMAL & CELL MODELS