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FLASH GENE

Symbol

TCF3

contributors: mct/shn - updated : 22-11-2019

HGNC name	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
HGNC id	11633

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

TCF3 , AGM8

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       fused with HLF in t(17;19)(q22;p13) in B cell acute lymphocytic leukemia and with PBX1 in acute lymphoblastic leukemia (at postnatal time) tumoral   deletion     in acute lymphoblastic leukaemia tumoral     --over   in colorectal cancer tissue compared with normal colorectal mucosa tumoral       gain of function in glioma tissues compared with normal brain tissues, potentially promoting glioma development through the AKT1 and ERK pathways

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	homozygous Tcf3 mutant mice develop to full term without apparent abnormalities, but then display a high rate of postnatal death
	E2A-null mutant mice fail to generate mature B cells
	homozygous Tcf3 mutant mice show retarded postnatal growth with blocking B cell differentiation
	mice expressing the E2A-HLF fusion gene using Ig enhancer and promoter exhibit abnormal development in the thymus and spleen and are susceptible to infection
	Tcf3/4-null primary mouse keratinocyte cultures show a growth defect with inability to maintain long-term epidermal homeostasis