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FLASH GENE
Symbol TCF3 contributors: mct/shn - updated : 22-11-2019
HGNC name transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
HGNC id 11633
ANIMAL & CELL MODELS
  • homozygous Tcf3 mutant mice develop to full term without apparent abnormalities, but then display a high rate of postnatal death
  • E2A-null mutant mice fail to generate mature B cells
  • homozygous Tcf3 mutant mice show retarded postnatal growth with blocking B cell differentiation
  • mice expressing the E2A-HLF fusion gene using Ig enhancer and promoter exhibit abnormal development in the thymus and spleen and are susceptible to infection
  • Tcf3/4-null primary mouse keratinocyte cultures show a growth defect with inability to maintain long-term epidermal homeostasis