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FLASH GENE
Symbol TCF3 contributors: mct/shn - updated : 22-11-2019
HGNC name transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
HGNC id 11633
ASSOCIATED DISORDERS
corresponding disease(s) TCF3 , AGM8
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral fusion      
fused with HLF in t(17;19)(q22;p13) in B cell acute lymphocytic leukemia and with PBX1 in acute lymphoblastic leukemia (at postnatal time)
tumoral   deletion    
in acute lymphoblastic leukaemia
tumoral     --over  
in colorectal cancer tissue compared with normal colorectal mucosa
tumoral       gain of function
in glioma tissues compared with normal brain tissues, potentially promoting glioma development through the AKT1 and ERK pathways
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • homozygous Tcf3 mutant mice develop to full term without apparent abnormalities, but then display a high rate of postnatal death
  • E2A-null mutant mice fail to generate mature B cells
  • homozygous Tcf3 mutant mice show retarded postnatal growth with blocking B cell differentiation
  • mice expressing the E2A-HLF fusion gene using Ig enhancer and promoter exhibit abnormal development in the thymus and spleen and are susceptible to infection
  • Tcf3/4-null primary mouse keratinocyte cultures show a growth defect with inability to maintain long-term epidermal homeostasis