| basic FUNCTION
| heterodimers between TCF3 and bHLH protein playing a major role in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation |
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potential role in renal fibrosis |
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controls proliferation and differentiation in many cell types including kidney epithelial cells  |
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can also acting as a tumor suppressor gene in B-cell precursor acute lymphoblastic leukemia |
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prevent lymphoma cell expansion, at least in part through regulation of GFI1B and modulation of GATA3 expression |
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promote the developmental progression of the entire spectrum of early hematopoietic progenitors and suppress an erythroid specific program of gene expression in alternative cell lineages |
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act to promote the developmental progression of the entire spectrum of early hematopoietic progenitors |
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E protein that binds the E-box elements, and participates in CASK regulation of CDKN1A expression |
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playing a role in long-term maintenance and wound repair of both epidermis and hair follicles, suggesting that TCF proteins have both Wnt-dependent and Wnt-independent roles in lineage determination |
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key transcription factor, with TCF4, that collaborate with beta-catenin in its established role in hair follicle stem cell activation |
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with TCF4 may be essential for establishing and maintaining all skin epithelial stem cells through Wnt-dependent and Wnt-independent roles |
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basic helix-loop-helix transcription factor involved in neuronal differentiation and survival |
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SCX and TCF3 might modulate the primary chondrogenesis by associating with the SOX9-related transcriptional complex, and by binding to the conserved E-box on COL2A1 promoter |
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SNAI1, SNAI2, and TCF3 can promote collective migration during branching morphogenesis of mammary epithelial tissues through key regulators of EMT (epithelial-mesenchymal transition) |
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essential within the neural ectoderm to maintain anterior character and that its interaction with Hesx1 ensures the repression of Wnt targets in the developing forebrain |
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essential within the neural ectoderm to maintain anterior character and that its interaction with Hesx1 ensures the repression of Wnt targets in the developing forebrain |
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TCF3 and ELL2, play important roles in the regulation of B cell development in the bone marrow and differentiation of mature B cells into plasma cells in the periphery, respectively |
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essential within the neural ectoderm to maintain anterior character and interaction with HESX1 ensures the repression of Wnt targets in the developing forebrain |
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plays critical roles in inducing IgK rearrangement by directly binding to and increasing chromatin accessibility at target gene segments |
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appears to act as a “lineage-survival oncogene” for Burkitt lymphoma (BL) |
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limit expression of GATA3 to facilitate T lymphocyte lineage commitment |
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ID2/TCF3 axis orchestrates T cell differentiation through the induction or repression of downstream transcription factors essential for effector and memory T cell differentiation |
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represses Wnt-CTNNB1 signaling and maintains neural stem cell population during neocortical development |
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novel role for TCF3, an essential transcription factor regulating embryonic and adult skin stem cell functions, as a key effector of epidermal wound repair |
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role of TCF3 in cell-fate decision is more complex than previously appreciated and is highly dependent on cellular context |
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a dynamic interplay of TCF3,TCF4 transcription factors governs MYC gene expression in colo-rectal cancer |
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is an essential regulator of early B cell development |
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TCF3 together with TCF4 controlled germinal center (GC) B cell and plasma cell development |
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TCF3, TCF4 are central regulators of B cell immunity |
