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FLASH GENE

Symbol

LTA

contributors: np/ - updated : 23-05-2007

HGNC name	lymphotoxin alpha (TNF superfamily, member 1)
HGNC id	6709

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6p21.33      Physical location : 2.825.414 - 31.542.098
Synonym name	tumor necrosis factor ligand superfamily member 1
	tumor necrosis factor beta
Synonym symbol(s)	TNFB, TNFSF1, DASS-280D8.1, LT, LT-alpha, TNF-beta
EC.number	2.3.1.12

DNA

TYPE	functioning gene
STRUCTURE	2.22 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

Map	pter - HLA-B - FKBP1P1 - MICA - MICB - BAT1 - NFKBIL1 - LTA - LTB - KRT18P1 - HSPA1A - C2 C2 - cen

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000595 4 - 1386 NP_000586 - 205 - - NM_001159740 4 - 1459 NP_001153212 - 205 - -

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive pharynx         Lymphoid/Immune spleen           tonsils

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune T cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

an extracellular C terminus, bearing the ligand binding region

conjugated

GlycoP

mono polymer

homomer , heteromer , trimer

HOMOLOGY

Homologene

FAMILY

tumors necrosis factor (ligand) family

CATEGORY

signaling cytokine

SUBCELLULAR LOCALIZATION	plasma membrane
text	membrane protein type 2

basic FUNCTION

involved in the formation of secondary lymphoid organs during development and playing a role in apoptosis

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with LGALS2

cell & other

REGULATION

Other

regulated by LGALS2

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to myocardial infarction to early-onset leprosy to psoriatic arthritis

Variant & Polymorphism SNP , other	increased risk of myocardial infarction
	(LTA)+80 A allele was significantly associated with an increase in early-onset leprosy risk

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cardiovascular atheroma cardiac metabolism lipid   may represent a novel therapeutic route for the treatment of dyslipidemia

ANIMAL & CELL MODELS