Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TRAM2 contributors: mct/npt - updated : 29-03-2010
HGNC name translocation associated membrane protein 2
HGNC id 16855
Location 6p12.2      Physical location : 52.362.201 - 52.441.862
Synonym name
  • TRAM-like protein
  • translocating-chain-associating membrane protein-like sequence
    • Synonym symbol(s) CAT77, ZNFA3, KIAA0057, TRAML
    DNA
    TYPE functioning gene
    STRUCTURE 79.66 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 7065 - 370 - Onuchic (1999)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousspinal cord    
    Reproductivemale systemprostate   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C-terminal part of TRAM2 interacting with the Ca(2+) pump of the ER, SERCA2B
    • HOMOLOGY
    intraspecies homolog to TRAM1
    Homologene
    FAMILY
  • LASS1 family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in determining life span
  • playing a role in collagen type I expression in hepatic stellate cells (HSCs) and fibroblasts
  • required for the biosynthesis of type I collagen by coupling the activity of SERCA2b with the activity of the translocon
  • facilitates proper folding of type I collagen (Pregizer 2007)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SERCA2B
  • interacting with RUNX2 (may regulate TRAM2 expression in a BMP-dependent manner, and TRAM2 may participate in the overall osteogenic function of RUNX2) (Pregizer 2007)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS