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FLASH GENE

Symbol

RHAG

contributors: - updated : 07-01-2005

HGNC name	Rhesus blood group-associated glycoprotein
HGNC id	10006

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	RHNR RH-null syndrome
Location	6p21.1-p11      Physical location : 49.572.892 - 49.604.587
Synonym symbol(s)	RH50, RH50A, RH2

DNA

TYPE	functioning gene
STRUCTURE	31.00 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

motif

repetitive sequence   ALU   long interspersed repetitive elements

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic erythrocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

twelve transmembrane domains (12TM)

conjugated

GlycoP

HOMOLOGY

interspecies

homolog to murine Rhag

intraspecies

homolog to RH (30kD components (see RH)),highly

Homologene

FAMILY

RH family

CATEGORY

structural protein , antigen

SUBCELLULAR LOCALIZATION	plasma membrane
text	integral membrane protein

basic FUNCTION	strictly required for the transport of antigen to cell surface of red blood cells
	facilitating NH3 movement across the red blood cells membrane

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	mediating uptake of ammonium across cell membranes

PATHWAY

metabolism

signaling

a component

component of the RH antigen multisubunit complex,required for transport and assembly of the Rh membrane complex to the red blood cell surface

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

RHNR

related resource

Blood Group Antigen Mutation Database

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS