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FLASH GENE

Symbol

TNFRSF1B

contributors: mct/npt - updated : 15-04-2014

HGNC name	tumor necrosis factor receptor superfamily, member 1B
HGNC id	11917

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     in neuroblastoma

Susceptibility

to familial combined hyperlipidemia to systemic lupus erythematosis and to narcolepsy to coronary artery disease and to osteoporosis to Mycobacterium tuberculosis infection

Variant & Polymorphism other	A593 - T598 - C620 haplotype decreased bone mineral density
	functional haplotype in the 3 prime untranslated region of TNFRSF1B is associated with tuberculosis

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurology neurodegenerative   activation of TNFSF1B signaling by TNC-scTNFSF1B appears a promising strategy to ameliorate neurodegenerative processes.

ANIMAL & CELL MODELS