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FLASH GENE
Symbol TNFRSF1B contributors: mct/npt - updated : 15-04-2014
HGNC name tumor necrosis factor receptor superfamily, member 1B
HGNC id 11917
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four extracytoplasmic cysteine-rich pseudorepeats typical for the TNFR superfamily
  • a preligand assembly domain (PLAD) in CRD1 mediating ligand-independent receptor assembly and signaling
  • a small cytoplasmic domain with the serine/threonine kinase but lacking a DEATH domain
  • mono polymer homomer , trimer
    HOMOLOGY
    Homologene
    FAMILY
  • tumor necrosis factor receptor superfamily
  • CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    intracellular,nucleus
    intracellular,nuclear envelope
    text type I transmembrane protein
    basic FUNCTION
  • may be playing a role in protecting neurons from apoptosis by stimulating antioxidative pathways
  • leading to selective ASK1 ubiquitination and degradation in proteasomes
  • leading to TRAF2 ubiquitination and subsequent proteasomal degradation
  • endogenous TNFRSF1B/TNFRSF1A signaling pathway in polymicrobial sepsis reduces neutrophil recruitment contributing to mortality
  • critical role for endothelial TNFR2 in ischemia-mediated adaptive angiogenesis
  • through TNFRSF1B, microglia may contribute to the counter-regulatory response activated in neuropathological conditions
  • is involved in tissue regeneration and neuroprotection
  • TNFRSF1A, TNFRSF1B were required for IRF1-IFNB signaling and, in human endothelial cells
  • TNFRSF1A, TNFRSF1B activities are required for the TNF-induced proinflammatory response
  • potential mechanism for the neuroprotective role of TNFRSF1B in oligodendrocyte progenitor cells (OPCs)
  • can protect OPCs from oxidative stress by expression of anti-apoptotic proteins and further underscore the potential of TNFRSF1B in neuroregenerative processes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • TNFRSF1B/SMURF2 complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SMURF2 and TRAF2 (SMURF2-induced TNFRSF1B ubiquitination and subcellular relocalization of TNFRSF1B and TRAF2 enables the specific activation of the JNK pathway)
  • may contribute to the tumor-promoting roles of STAT3
  • PADI2 regulates the expression of the TNFRSF1B, ADAMTS9, and RAB6B transcripts in mast cells
  • TNFRSF1B-dependent homeostasis of regulatory T cells as a player in TNF-induced experimental metastasis
  • TRAF2 is critical for either TNFRSF1A- or TNFRSF1B-mediated activation of NFKB and mitogen-activated protein kinase (MAPK) signaling, as well as for target gene expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in neuroblastoma
    Susceptibility
  • to familial combined hyperlipidemia
  • to systemic lupus erythematosis and to narcolepsy
  • to coronary artery disease and to osteoporosis
  • to Mycobacterium tuberculosis infection
  • Variant & Polymorphism other
  • A593 - T598 - C620 haplotype decreased bone mineral density
  • functional haplotype in the 3 prime untranslated region of TNFRSF1B is associated with tuberculosis
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerative 
    activation of TNFSF1B signaling by TNC-scTNFSF1B appears a promising strategy to ameliorate neurodegenerative processes.
    ANIMAL & CELL MODELS