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FLASH GENE
Symbol TNFRSF1B contributors: mct/npt - updated : 15-04-2014
HGNC name tumor necrosis factor receptor superfamily, member 1B
HGNC id 11917
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
Endocrinepancreas   moderately
Nervousbrain     Homo sapiens
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousoligodendrocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four extracytoplasmic cysteine-rich pseudorepeats typical for the TNFR superfamily
  • a preligand assembly domain (PLAD) in CRD1 mediating ligand-independent receptor assembly and signaling
  • a small cytoplasmic domain with the serine/threonine kinase but lacking a DEATH domain
  • mono polymer homomer , trimer
    HOMOLOGY
    Homologene
    FAMILY
  • tumor necrosis factor receptor superfamily
  • CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    intracellular,nucleus
    intracellular,nuclear envelope
    text type I transmembrane protein
    basic FUNCTION
  • may be playing a role in protecting neurons from apoptosis by stimulating antioxidative pathways
  • leading to selective ASK1 ubiquitination and degradation in proteasomes
  • leading to TRAF2 ubiquitination and subsequent proteasomal degradation
  • endogenous TNFRSF1B/TNFRSF1A signaling pathway in polymicrobial sepsis reduces neutrophil recruitment contributing to mortality
  • critical role for endothelial TNFR2 in ischemia-mediated adaptive angiogenesis
  • through TNFRSF1B, microglia may contribute to the counter-regulatory response activated in neuropathological conditions
  • is involved in tissue regeneration and neuroprotection
  • TNFRSF1A, TNFRSF1B were required for IRF1-IFNB signaling and, in human endothelial cells
  • TNFRSF1A, TNFRSF1B activities are required for the TNF-induced proinflammatory response
  • potential mechanism for the neuroprotective role of TNFRSF1B in oligodendrocyte progenitor cells (OPCs)
  • can protect OPCs from oxidative stress by expression of anti-apoptotic proteins and further underscore the potential of TNFRSF1B in neuroregenerative processes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • TNFRSF1B/SMURF2 complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SMURF2 and TRAF2 (SMURF2-induced TNFRSF1B ubiquitination and subcellular relocalization of TNFRSF1B and TRAF2 enables the specific activation of the JNK pathway)
  • may contribute to the tumor-promoting roles of STAT3
  • PADI2 regulates the expression of the TNFRSF1B, ADAMTS9, and RAB6B transcripts in mast cells
  • TNFRSF1B-dependent homeostasis of regulatory T cells as a player in TNF-induced experimental metastasis
  • TRAF2 is critical for either TNFRSF1A- or TNFRSF1B-mediated activation of NFKB and mitogen-activated protein kinase (MAPK) signaling, as well as for target gene expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in neuroblastoma
    Susceptibility
  • to familial combined hyperlipidemia
  • to systemic lupus erythematosis and to narcolepsy
  • to coronary artery disease and to osteoporosis
  • to Mycobacterium tuberculosis infection
  • Variant & Polymorphism other
  • A593 - T598 - C620 haplotype decreased bone mineral density
  • functional haplotype in the 3 prime untranslated region of TNFRSF1B is associated with tuberculosis
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerative 
    activation of TNFSF1B signaling by TNC-scTNFSF1B appears a promising strategy to ameliorate neurodegenerative processes.
    ANIMAL & CELL MODELS