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FLASH GENE
Symbol CP contributors: mct - updated : 29-11-2019
HGNC name ceruloplasmin (ferroxidase)
HGNC id 2295
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three F5/8 type A domains
  • six plastocyanin-like domains
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Cp
    Homologene
    FAMILY
  • multicopper oxidase family
    • CATEGORY enzyme , secretory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • ferroxidase, iron (II): oxygen oxidoreductase
  • multicopper oxidase of plasma (Sokolov 2008)
  • should provide a protective shield against inadvertent oxidant production by MPO during inflammation
  • HEPH and CP are important for the prevention of glial iron accumulation and thus may be protective against oxidative damage
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text essential for iron homeostasis and neuronal survival
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • interacts with myeloperoxidase (MPO), and inhibits its peroxidase and chlorinating activity (Sokolov 2008)
  • HEPH may compensate for the loss of CP in a region-specific manner
  • Ceruloplasmin was the predominant protein associated with MPO
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CP
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    of hephaestin and ceruloplasmin induces a serious systemic iron deficiency and disrupts iron homeostasis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS