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FLASH GENE

Symbol

CP

contributors: mct - updated : 29-11-2019

HGNC name	ceruloplasmin (ferroxidase)
HGNC id	2295

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Nervous brain       moderately Homo sapiens Visual eye retina

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial sensory visual

cells

System Cell Pubmed Species Stage Rna symbol Nervous astrocyte Homo sapiens Nervous glia

cell lineage
cell lines
fluid/secretion	plasma

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	three F5/8 type A domains
	six plastocyanin-like domains

conjugated

GlycoP

HOMOLOGY

interspecies

ortholog to murine Cp

Homologene

FAMILY

multicopper oxidase family

CATEGORY

enzyme , secretory

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	ferroxidase, iron (II): oxygen oxidoreductase
	multicopper oxidase of plasma (Sokolov 2008)
	should provide a protective shield against inadvertent oxidant production by MPO during inflammation
	HEPH and CP are important for the prevention of glial iron accumulation and thus may be protective against oxidative damage

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	essential for iron homeostasis and neuronal survival

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+

protein	interacts with myeloperoxidase (MPO), and inhibits its peroxidase and chlorinating activity (Sokolov 2008)
	HEPH may compensate for the loss of CP in a region-specific manner
	Ceruloplasmin was the predominant protein associated with MPO

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CP

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   deletion     of hephaestin and ceruloplasmin induces a serious systemic iron deficiency and disrupts iron homeostasis

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS