Symbol
| ITGA6
| contributors: mct - updated : 23-04-2012
|
HGNC name
| integrin, alpha 6
|
HGNC id
| 6142
|
corresponding disease(s)
|
EBJPAA
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --over
|  
|
in glioblastoma stem cells | tumoral
|  
|  
| --over
|  
|
in precursor B-cell acute lymphoblastic leukemia | constitutional
|  
|  
| --low
|  
|
identified transiently engrafting multipotent progenitors (MPPs) | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
Therapy target
|
System | Type | Disorder | Pubmed |
cancer | brain | glioma/neuroblstoma | |
promising antiglioblastoma therapy | cancer | reproductive | prostate | |
ITGA6 cleavage permits extravasation of human prostate cancer cells from circulation to bone and can be manipulated to prevent metastasis | cancer | reproductive | breast | |
potential therapeutic target aimed at tumour-generating subsets of breast cancer cells |
| | | |