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FLASH GENE

Symbol

ITGB2

contributors: mct - updated : 08-03-2012

HGNC name	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
HGNC id	6155

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth       lowly Lymphoid/Immune spleen       predominantly   thymus       predominantly   tonsils       highly Reproductive female system placenta     lowly   male system prostate     lowly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     lowly Connective       moderately Muscular striatum skeletal   lowly

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte

cell lineage
cell lines
fluid/secretion	blood

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a VWFA-like domain

mono polymer

heteromer , dimer

HOMOLOGY

interspecies	homolog to rattus Itgb2 (81.38 pc)
	homolog to murine Itgb2 (82.05 pc)

Homologene

FAMILY

integrin beta chain family

CATEGORY

adhesion , immunity/defense , antigen , receptor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
	regulates T cell activation and signal transduction through the immunological synapse
	function of ITGB2 is to enhance TCR signaling through the immunological synapse and deliver distinct signals in CD8+ T cell activation
	unique role in T cell Ca2+ signaling and ITGB2-dependent Ca2+ entry proceeds via a mechanism separate from store-operated Ca2+ entry
	ITGB2 signaling is required for the generation of central memory CD8(+) T cells in priming phase
	controls many functions of T lymphocytes and is particularly essential during lymphocyte migration from blood into tissues
	plays a key role in regulating neutrophil recruitment, CXCL2 formation and tissue injury in the pancreas
	mediating T cell migration, essential for immune surveillance and response
	pivotal role of neutrophil ITGB2 and ROS in this process provides a potential target for modulating immune responses

CELLULAR PROCESS	cell life, cell death/apoptosis
	cell communication

PHYSIOLOGICAL PROCESS

immunity/defense , inflammation

PATHWAY

metabolism

signaling

signal transduction

a component	common constituent of LFA-1, Mac-1 and p150, 95 antigens
	dimerizing with ITGAL, ITGAM, ITGAX (see symbols)
	ITGB2/LCK/ZAP70 complex is in position to initiate the rapid adhesion strengthening and migration necessary for T-lymphocyte responses when stimulated vasculature is encountered at sites of infection or injury

INTERACTION

DNA

RNA

small molecule

protein	ILK, GNB2L1, ITGB1BP, ITGAL, ITGAM, ITGAX
	SPN interacts with BSG and ITGB2 in two distinct but similarly reorganized complexes
	interacting with RAP1A (mediates ITGB2 activation and ITGB2-mediated adhesion)
	interacting with calpain 2, that controls turnover of ITGB2 adhesions on migrating T lymphocytes
	is constitutively associated with the protein tyrosine kinases LCK and ZAP70 (pMID: 21200022)
	interaction with CTSZ (cysteine carboxypeptidase, that is involved in the regulation of T cell migration by interaction with ITGB2)
	FERMT3 is a key lymphocyte function-associated antigen-1 (ITGB2) coactivator
	interacting with CYTH1 (regulates adhesion and the transendothelial migration of monocytes, dendritic cells and T lymphocytes through activation of ITGB2)
	interacting with ANGPT2 (is a novel, endothelial-derived regulator of myeloid cell infiltration that modulates ITGB2-mediated adhesion in a paracrine manner)
	interacting with TIAM1 (TCR-induced activation of ITGB2 involves signaling through TIAM1)
	FERMT3 is enriched within focal clusters of high-affinity ITGB2, which promoted physical linkage with ORAI1
	binding of ITGB2 to ICAM1 has a downstream effect in the recruitment of kindlin 3 to the membrane that is PH-dependent
	FOLR2 is a novel ITGAM/ITGB2 regulator for trafficking and homing of a subset of macrophages on collagen

cell & other

unstimulated and activated endothelial cells

REGULATION

Other	CTSZ cleavage of ITGB2 regulates talin-binding and ITGB2 affinity in T cells
	regulation of ITGB2 activity allows dendritic cells to actively control antigen-driven T-cell proliferation and effective immune responses

ASSOCIATED DISORDERS

corresponding disease(s)

LAD1

related resource

ITGB2base: Mutation registry for Leucosyte adhesion deficiency I (LAD-I)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed digestive     targeting ITGB2 may be a useful approach to protect against pathological inflammation in the pancreas

ANIMAL & CELL MODELS