|
| induction of Osteopontin expression is strongly associated with rat ventricular hypertrophy ( | |
Osteopontin null mutant mice are fertile but showed a significantly decreased level of debridement, greater disorganization of matrix, and an alteration of collagen fibrillogenesis leading to small diameter collagen fibrils ( |
|
Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption compared with wild-type mice ( |
|
Mice deficient in osteopontin gene expression have severely impaired type-1 immunity to viral infection and bacterial infection and do not develop sarcoid-type granulomas ( |
|
Osteopontin-deficient mice were resistant to progressive autoimmune encephalomyelitis and had frequent remissions, and myelin-reactive T cells in OPN-/- mice produced more interleukin 10 and less interferon-gamma ( |
|
SLAYGLR sequence of murine osteopontin, is critically involved in the pathogenesis of a murine model of rheumatoid arthritis ( |
|
OPN- and NKT cell-deficient mice were refractory to Concanavalin A-induced hepatitis ( |
|
Obese mice lacking osteopontin displayed improved insulin sensitivity in the absence of an effect on diet-induced obesity, body composition, or energy expenditure, and exhibited decreased markers of inflammation, both in adipose tissue and systemically ( |
|
Periapical bone loss associated with endodontic infection was significantly more severe in OPN-deficient mice compared with wild-type 3 weeks after infection, and was associated with increased areas of inflammation ( |