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Symbol SPP1 contributors: mct/shn - updated : 22-04-2016
HGNC name secreted phosphoprotein 1
HGNC id 11255
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
overexpressed in autoimmune demyelinating disease (multiple sclerosis) and in Dianzani autoimmune/lymphoproliferative disease
constitutional     --low  
in Crohn disease of the terminal ileon
tumoral     --over  
in breast cancer in progression
tumoral     --over  
in chronic myelogenous leukemia (CML) patients because SPP1 is deregulated by BCR-ABL oncogene
tumoral     --over  
in glioma
tumoral     --over  
in osteosarcomas correlating with better overall survival, event-free survival and relapse free survival at diagnosis
tumoral     --over  
dramatically elevated in hepatocellular carcinoma (HCC) tissues with metastasis and correlates with poorer overall survival and higher recurrence rate
  • to systemic lupus erythematosus
  • to glioma
  • Variant & Polymorphism other
  • 707 C->T associated with systemic lupus
  • association between SPP1 promoter polymorphisms and glioma risk
  • rs4754 may be a susceptible factor for Vogt-Koyanagi-Harada disease in a Chinese Han population (
  • Candidate gene
    Therapy target
    SPP1 antibody may provide a potential therapeutic target for the treatment of T cell-mediated immune diseases
    important therapeutic target in allergic airway disease
    might be a valuable target for developing novel antiangiogenesis therapy for treatment of cancer
    with S100A6, may be promising diagnostic markers and therapeutic targets for hepatocellular carcinoma
  • induction of Osteopontin expression is strongly associated with rat ventricular hypertrophy (
  • Osteopontin null mutant mice are fertile but showed a significantly decreased level of debridement, greater disorganization of matrix, and an alteration of collagen fibrillogenesis leading to small diameter collagen fibrils (
  • Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption compared with wild-type mice (
  • Mice deficient in osteopontin gene expression have severely impaired type-1 immunity to viral infection and bacterial infection and do not develop sarcoid-type granulomas (
  • Osteopontin-deficient mice were resistant to progressive autoimmune encephalomyelitis and had frequent remissions, and myelin-reactive T cells in OPN-/- mice produced more interleukin 10 and less interferon-gamma (
  • SLAYGLR sequence of murine osteopontin, is critically involved in the pathogenesis of a murine model of rheumatoid arthritis (
  • OPN- and NKT cell-deficient mice were refractory to Concanavalin A-induced hepatitis (
  • Obese mice lacking osteopontin displayed improved insulin sensitivity in the absence of an effect on diet-induced obesity, body composition, or energy expenditure, and exhibited decreased markers of inflammation, both in adipose tissue and systemically (
  • Periapical bone loss associated with endodontic infection was significantly more severe in OPN-deficient mice compared with wild-type 3 weeks after infection, and was associated with increased areas of inflammation (