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Symbol SPP1 contributors: mct/shn - updated : 22-04-2016
HGNC name secreted phosphoprotein 1
HGNC id 11255
  • induction of Osteopontin expression is strongly associated with rat ventricular hypertrophy (
  • Osteopontin null mutant mice are fertile but showed a significantly decreased level of debridement, greater disorganization of matrix, and an alteration of collagen fibrillogenesis leading to small diameter collagen fibrils (
  • Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption compared with wild-type mice (
  • Mice deficient in osteopontin gene expression have severely impaired type-1 immunity to viral infection and bacterial infection and do not develop sarcoid-type granulomas (
  • Osteopontin-deficient mice were resistant to progressive autoimmune encephalomyelitis and had frequent remissions, and myelin-reactive T cells in OPN-/- mice produced more interleukin 10 and less interferon-gamma (
  • SLAYGLR sequence of murine osteopontin, is critically involved in the pathogenesis of a murine model of rheumatoid arthritis (
  • OPN- and NKT cell-deficient mice were refractory to Concanavalin A-induced hepatitis (
  • Obese mice lacking osteopontin displayed improved insulin sensitivity in the absence of an effect on diet-induced obesity, body composition, or energy expenditure, and exhibited decreased markers of inflammation, both in adipose tissue and systemically (
  • Periapical bone loss associated with endodontic infection was significantly more severe in OPN-deficient mice compared with wild-type 3 weeks after infection, and was associated with increased areas of inflammation (