basic FUNCTION
| controling the activity of glucokinase in liver but possibly also in some areas of the central nervous system, suggesting that it could play a role in body mass control |
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inhibiting glucokinase by forming an inactive complex with this enzyme |
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GCK and GCKR function as key glucose sensors ( |
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is the most important post-transcriptional regulator of GCK in the liver, and participates in the modulation of GCK activity and location depending upon changes in glucose levels |
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releases GCK in a sigmoidal manner in response to glucose concentration by restricting a structural rearrangement of the GCK small domain via a single ion pair |