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FLASH GENE
Symbol PPP1CB contributors: mlc/npt - updated : 01-04-2015
HGNC name protein phosphatase 1, catalytic subunit, beta isoform
HGNC id 9282
Location 2p23.2      Physical location : 28.974.613 - 29.025.805
Synonym name
  • protein phosphatase 1-delta
  • serine/threonine protein phosphatase PP1-beta catalytic subunit
  • epididymis secretory sperm binding protein Li 80p
  • protein phosphatase 1, catalytic subunit, beta isoform
  • protein phosphatase 1, catalytic subunit, delta isoform
  • Synonym symbol(s) MGC3672, PP-1B, PPP1CD, HEL-S-80p, PP1B, PP1beta
    EC.number 3.1.3.16/ 3.1.3.53
    DNA
    TYPE functioning gene
    STRUCTURE 51.19 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure a polymorphic (CA) repeat marker (D2S1237)
    MAPPING cloned Y linked   status provisional
    Physical map
    NRBP 2p23 nuclear receptor binding protein KCP3 SLB 2p23.3 selective LIM binding factor, rat homolog FRCP1 GCKR 2p23.3-p23.2 glucokinase (hexokinase 4) regulatory protein DKFZp434G118 ZNF512 2p23 zinc finger protein 512 FLJ13646 2p23.3 hypothetical protein FLJ13646 XAB1 2p23.3 XPA binding protein 1 STAF65(gamma) 2pter-p25.1 SPTF-associated factor 65 gamma SLC4A1AP 2p23.3 solute carrier family 4 (anion exchanger), member 1, adaptor protein MRPL33 2p22 mitochondrial ribosomal protein L33 RBSK BRE 2p23.3 brain and reproductive organ-expressed (TNFRSF1A modulator) FOSL2 2p23-p22 FOS-like antigen 2 FLJ23306 2p23.3 hypothetical protein FLJ23306 LOC388937 2 similar to Phospholipase PLB PPP1CB 2p23 protein phosphatase 1, catalytic subunit, beta isoform SPY1 2p23.3 speedy FLJ20628 2p23.3 hypothetical protein FLJ20628 KIAA0007 2p23.3 KIAA0007 protein LOC388938 2 LOC388938 LOC165186 2p23.3 similar to RIKEN cDNA 4632412N22 gene LOC388939 2 similar to BC027072 protein FLJ21069 2p23.3 hypothetical protein FLJ21069 ALK 2p23 anaplastic lymphoma kinase (Ki-1)
    RNA
    TRANSCRIPTS type messenger
    text three alternate splicing variants (Barker)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 4991 37.2 327 - Flores-Delgado (2007)
    9 - 4786 37.2 327 - Flores-Delgado (2007)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Reproductivefemale systemuteruscervix highly
     female systembreastmammary gland highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Ppp1cb
    homolog to C.elegans F29f11.6
    intraspecies homolog to PPP1CA
    Homologene
    FAMILY
  • PPP family of phophatases
  • PP-1 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • serine/threonine protein phosphatase 1, catalytic subunit, essentiel for cell division
  • regulating glycogen metabolism, muscle contractility, protein synthesis, ionic conductances and long-term synaptic plasticity
  • catalytic subunit of protein phosphatase 1
  • PPP1CA and PPP1CB - are capable of compensating the loss of PPP1CC in every tissue except in testis
  • CELLULAR PROCESS cell cycle, division
    protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
  • PPP1CB-NPM pathway contributes to cellular DNA damage response
  • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Mn2+
  • protein
  • interacting with BRCA1 (contributing to the development of breast cancer)
  • interacted with TRIM28 only in response to genotoxic stress
  • physiological NPM phosphatase under both the genotoxic stress and growth conditions
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    YPEL5/PPP1CB in Chronic lymphocytic leukemia (CLL) with N-terminal truncation caused by YPEL5/PPP1CB fusion decreasing the phosphatase activity of PPP1CB enzyme
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS