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FLASH GENE
Symbol GCKR contributors: mct - updated : 12-06-2015
HGNC name glucokinase (hexokinase 4) regulatory protein
HGNC id 4196
Location 2p23.3      Physical location : 27.719.705 - 27.746.548
Synonym symbol(s) FGQTL5, GKRP
EC.number 2.7.1.2
DNA
TYPE functioning gene
STRUCTURE 26.84 kb     19 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Map pter - PPP1CB - D2S1237 - D2S220 - KHK KHK - GCKR - D2S165 - cen
Authors Hayward (97)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 - 2197 - 625 - 1998 9570959
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Endocrinepancreas    
Reproductivemale systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text liver testis
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
one sis domain
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme , regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
intracellular,cytoplasm,cytosolic
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • controling the activity of glucokinase in liver but possibly also in some areas of the central nervous system, suggesting that it could play a role in body mass control
  • inhibiting glucokinase by forming an inactive complex with this enzyme
  • GCK and GCKR function as key glucose sensors (
  • is the most important post-transcriptional regulator of GCK in the liver, and participates in the modulation of GCK activity and location depending upon changes in glucose levels
  • releases GCK in a sigmoidal manner in response to glucose concentration by restricting a structural rearrangement of the GCK small domain via a single ion pair
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting non-covalently with GCR and inhibiting it in presence of fructose-6-phosphate
  • GCK regulates glucose storage and disposal in the liver where its activity is regulated by glucokinase regulatory protein, GCKR
  • binds to a super-open conformation of GCK mainly through hydrophobic interaction, inhibiting the GCK activity by locking a small domain of GCK
  • SIRT2-dependent GCKR deacetylation improves impaired hepatic glucose uptake (HGU)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to hepatic fat accumulation along with large VLDL and triglyceride levels
  • to familial type 2 diabetes
  • Variant & Polymorphism SNP
  • rs1260326 in GCKR is associated with hepatic fat accumulation along with large VLDL and triglyceride levels
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • liver content of GCK was reduced in Irs2(-/-) mice as compared with controls, although GCKR levels were similar