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FLASH GENE
Symbol LAMB2 contributors: mct - updated : 26-02-2011
HGNC name laminin, beta 2 (laminin S)
HGNC id 6487
Corresponding disease
MCCNS microcoria-congenital nephrosis and myasthenic syndrome
Location 3p21.31      Physical location : 49.158.547 - 49.170.599
Synonym name
  • laminin S
  • laminin B1s chain
  • laminin subunit beta-2
  • Synonym symbol(s) LAMS
    DNA
    TYPE functioning gene
    STRUCTURE 12.05 kb     32 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map pter - D3S4594 - LAMB2L - LAMB2 - QARS - DAG1 - cen
    Authors Durkin (99)
    Physical map
    LOC344651 3p21.31 hypothetical LOC344651 SLC26A6 3p21 solute carrier family 26, member 6 CELSR3 3p24.1-p21.2 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila) AF3P21 3p21 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila) IHPK2 3p21.31 inositol hexaphosphate kinase 2 PRKAR2A 3p21.3-p21.2 protein kinase, cAMP-dependent, regulatory, type II, alpha SLC25A20 3p21.31 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 ARIH2 3p21.2-p21.3 ariadne homolog 2 (Drosophila) PH-4 3p21.31 hypoxia-inducible factor prolyl 4-hydroxylase WDR6 15q21 WD repeat domain 6 FLJ10496 3p21.31 hypothetical protein FLJ10496 DKFZP564J0123 3p21.31 nuclear protein E3-3 IMPDH2 3p21.2 IMP (inosine monophosphate) dehydrogenase 2 FLJ20259 3p21.31 FLJ20259 protein QARS 3p21.3-p21.2 glutaminyl-tRNA synthetase USP19 3p21.3-p14.2 ubiquitin specific protease 19 LAMB2 3p21.3-p21.2 laminin, beta 2 (laminin S) FLJ12800 3p21.31 hypothetical protein FLJ12800 MGC35097 3p21.31 hypothetical protein MGC35097 LOC339834 3p21.31 hypothetical protein LOC339834 FLJ43654 3p21.31 FLJ43654 protein USP4 3p21.31 ubiquitin specific protease 4 (proto-oncogene) GPX1 3p21.2 glutathione peroxidase 1 ARHA 3p21.2 ras homolog gene family, member A TCTA 3p21 T-cell leukemia translocation altered gene AMT 3p21.2 aminomethyltransferase (glycine cleavage system protein T) NICN1 3p21.31 nicolin 1 DAG1 3p21.2-p21.1 dystroglycan 1 (dystrophin-associated glycoprotein 1) BSN 3p21.31 bassoon (presynaptic cytomatrix protein)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    32 - 5817 - 1798 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   lowly
    Endocrinethyroid   moderately
    Lymphoid/Immunespleen   moderately
    Nervousnervecranial nerve  highly
     spinal cord   moderately
    Reproductivefemale systemuterus  highly
    Respiratorylung   moderately
     respiratory tracttrachea  moderately
    Urinarykidneynephronrenal capsuleglomerulushighly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Connectivebone  highly
    Lymphoid    
    Membranebasement   
    Muscularsmoothciliary muscle  
    Muscularsmoothiris  
    Muscularstriatumskeletal  
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text embryonic tissue at a moderately level
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 4 laminin A/neurexin/sex hormone-binding (LNS) globular domains separated by
  • 13 EGF-like motifs within the N terminal short arm allowing the self assembly of chains through interactions of the most terminal globular domain (VI)
  • a long arm composed of heptad repeats typical of an cell alpha helical coiled-coil protein
  • C-terminal region of beta chains is involved in laminin recognition by integrins and modulates the binding affinities of laminins toward X2-type integrins
  • conjugated GlycoP
    mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to rattus Lamb2 (88.04 pc)
    homolog to murine Lamb2 (88.42 pc)
    intraspecies homolog to LAMB1
    Homologene
    FAMILY
  • laminin family
  • CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION extracellular
    text glomeruli, nerve fascicle perineurium, vascular, basement membrane of neuromuscular junction (matrix and synaptic cleft of the neuromuscular junction)
    basic FUNCTION
  • mediating the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components
  • playing a role in anchoring as well as differentiation of podocytes foot processes
  • basement membrane protein laminin beta2, which is incorporated in specific heterotrimeric laminin isoforms
  • essential component of the basement membrane
  • CELLULAR PROCESS cell life, differentiation
    cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • constituent of basement membrane zone
  • heterotrimerizing with laminin alpha and laminin gamma subunits
  • bÍta subunit of laminin 3, laminin 4, laminin 7, laminin 11, laminin 13 and laminin 15
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding directly to voltage-gated calcium channels
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MCCNS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS