Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

DDX1

contributors: mct/pgu - updated : 13-03-2023

HGNC name	DEAD (Asp-Glu-Ala-Asp) box polypeptide 1
HGNC id	2734

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   amplification     co-amplified with MYCN in neuroblastoma tumoral   amplification     in retinoblastoma, neuroblastoma, lung small cell carcinoma with poor prognosis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive colon DDX1-LGR5 axis could be a new drug target for colorectal cancer

ANIMAL & CELL MODELS

Ddx1 knockout in early mouse embryos disrupts calcium distribution, and increases mitochondria membrane potential, mitochondrial activity, and reactive oxygen species