Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DDX1 contributors: mct/pgu - updated : 13-03-2023
HGNC name DEAD (Asp-Glu-Ala-Asp) box polypeptide 1
HGNC id 2734
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   amplification    
co-amplified with MYCN in neuroblastoma
tumoral   amplification    
in retinoblastoma, neuroblastoma, lung small cell carcinoma with poor prognosis
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerdigestivecolon
DDX1-LGR5 axis could be a new drug target for colorectal cancer
ANIMAL & CELL MODELS
  • Ddx1 knockout in early mouse embryos disrupts calcium distribution, and increases mitochondria membrane potential, mitochondrial activity, and reactive oxygen species