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FLASH GENE
Symbol DDX1 contributors: mct/pgu - updated : 18-11-2013
HGNC name DEAD (Asp-Glu-Ala-Asp) box polypeptide 1
HGNC id 2734
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a SPRY domain
  • one helicase ATP-binding domain
  • one helicase C terminal domain
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine ddx1 (97.6pc)
    homolog to rattus Ddx1 (97.7pc)
    Homologene
    FAMILY
  • DEAD box helicase family
  • DDX1 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus
    basic FUNCTION
  • RNA helicase with RNA dependent ATPase activity
  • is required for testicular tumorigenesis
  • specific roles in differentiated cells
  • cofactor in various biological processes
  • is required for both Rev activity and HIV production from infected cells
  • DDX3X, DDX1 and DHX9 are among the helicases that are required for the replication of a diverse range of viruses
  • DDX1 and DDX3X DEAD-box RNA helicases are known to be required for efficient HIV-1 Rev-dependent RNA export
  • CELLULAR PROCESS cell cycle
    cell life, proliferation/growth
    nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS development
    text spliceosome assembly proliferation
    PATHWAY
    metabolism
    signaling
    a component
  • DDX1-DDX21-DHX36 complex represents a dsRNA sensor that uses the TICAM1 pathway to activate type I IFN responses in the cytosol of myeloid dendritic cells (mDCs)
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP binding
  • protein
  • interacting with RELA, recruiting it to NF-KB-binding promoter sequences
  • binding HIV Regulator of virion (Rev) protein, hwihc is required for nuclear export of viral transcripts v)
  • acts potentially as a cellular cofactor by promoting oligomerization of Rev on the Rev response element (RRE)
  • subcellular localization of KHSRP is regulated by competing interactions with DDX1 or 14-3-3
  • cell & other
    REGULATION
    Other phosphorylated by ATM, phosphorylation enhanced by ionizing radiation, suggesting a role in the repair of dsDNA breaks
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    co-amplified with MYCN in neuroblastoma
    tumoral   amplification    
    in retinoblastoma, neuroblastoma, lung small cell carcinoma with poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS