SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,cytosolic,granule
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| intracellular,nucleus,nucleoplasm
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| basic FUNCTION
| RNA helicase with RNA dependent ATPase activity |
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is required for testicular tumorigenesis  |
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specific roles in differentiated cells |
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cofactor in various biological processes |
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is required for both Rev activity and HIV production from infected cells |
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DDX3X, DDX1 and DHX9 are among the helicases that are required for the replication of a diverse range of viruses |
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DDX1 and DDX3X DEAD-box RNA helicases are known to be required for efficient HIV-1 Rev-dependent RNA export |
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plays an important role in tRNA and mRNA processing, is involved in tumor progression and is also hijacked by several virus families such as HIV-1 for replication and nuclear export |
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potential role for DDX1 in resolving RNA-DNA structures that accumulate at DSBs located at sites of active transcription |
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DDX1 and RIF1 have different nucleic acid requirements for accumulation at DSBs, with RNA-DNA hybrids required for DDX1 accrual at DSBs, and single-strand RNA required for accumulation of RIF1 at these sites |
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important role for DDX1 in the regulation of gene alternative splicing and insulin secretion in pancreatic beta cells |
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novel role for DDX1 in maintaining cytoplasmic mRNA levels in cells exposed to oxidative stress |
