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FLASH GENE

Symbol

YARS2

contributors: mct - updated : 22-09-2015

HGNC name	tyrosyl-tRNA synthetase 2, mitochondrial
HGNC id	24249

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001040436 5 - 2179 NP_001035526 - 477 - 2005 15840810

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly Reproductive female system uterus cervix   highly   female system placenta     highly   male system testis     highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

ortholog to rattus norvegicus RGD31696

Homologene

FAMILY

class-I aminoacyl-tRNA synthetase family

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,matrix
	intracellular,cytoplasm,cytosolic

basic FUNCTION	tyrosine-tRNA ligase activity
	catalyzes covalent binding of tyrosine to its cognate tRNA (Riley (2010)
	likely increased requirement for YARS2 as muscle cells differentiate

CELLULAR PROCESS

protein, translation/synthesis

PHYSIOLOGICAL PROCESS

text	protein biosynthesis ; tyrosyl-tRNA aminoacylation

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA	binding tRNA

small molecule	nucleotide,
	ATP

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MLASA2

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS