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FLASH GENE

Symbol

IFT81

contributors: mct - updated : 29-08-2019

HGNC name	intraflagellar transport 81 homolog (Chlamydomonas)
HGNC id	14313

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a calponin-homology domain within the IFT81 N-terminus and the highly basic N-terminus of IFT74 form a module for IFT of tubulin (
	a putative signal peptide
	four coiled-coil domains

HOMOLOGY

interspecies	homolog to murine Ift81 (92.9pc)
	homolog to rattus Cdv1 (92.7pc)

Homologene

FAMILY

CATEGORY

motor/contractile

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
text	expression level is increased with testis development

basic FUNCTION	may play an important role in sperm maturation
	tubulin binding by IFT81 was required for ciliogenesis
	two core IFT proteins IFT74 and IFT81 form a tubulin-binding module
	together, the IFT81 and IFT74 N-termini are crucial for flagellar assembly, and are likely to function as the main module for IFT of tubulin
	importance of IFT81 in the skeleton, and role in the anterograde transport complex
	involved in the bidirectional transport of ciliary proteins
	plays an essential role during spermatogenesis by modulating the assembly and elongation of the sperm flagella

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development , reproduction/sex

text	spermatogenesis
	cell differentiation

PATHWAY

metabolism

signaling

a component

core component of the IFT-B complex

INTERACTION

DNA

RNA

small molecule

protein	IFT81 and IFT74/72 directly interact to form a higher order oligomer consistent with a tetrameric complex
	IFT52 binds directly to four other IFT-B subunits, IFT81/74/27/HSPB11
	IFT74 and IFT81 interact directly through central and C-terminal coiled-coil domains, and the N termini of these proteins form a tubulin-binding module important for ciliogenesis
	together, the IFT81 and IFT74 N-termini are crucial for flagellar assembly, and are likely to function as the main module for IFT of tubulin

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SRTD19

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       in nephronophthisis and polydactyly

Susceptibility

Variant & Polymorphism

Candidate gene	candidate gene for nonsyndromic retinal dystrophy
Marker
Therapy target

ANIMAL & CELL MODELS