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FLASH GENE
Symbol IFT81 contributors: mct - updated : 29-08-2017
HGNC name intraflagellar transport 81 homolog (Chlamydomonas)
HGNC id 14313
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver   moderately
 pancreas exocrine   moderately
Endocrinepancreas    
Nervousbrain   lowly
Reproductivefemale systemovary  moderately
 female systemplacenta  lowly
 male systemprostate  lowly
 male systemtestis  predominantly
Respiratorylung   lowly
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a calponin-homology domain within the IFT81 N-terminus and the highly basic N-terminus of IFT74 form a module for IFT of tubulin (
  • a putative signal peptide
  • four coiled-coil domains
  • HOMOLOGY
    interspecies homolog to murine Ift81 (92.9pc)
    homolog to rattus Cdv1 (92.7pc)
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text expression level is increased with testis development
    basic FUNCTION
  • may play an important role in sperm maturation
  • tubulin binding by IFT81 was required for ciliogenesis
  • two core IFT proteins IFT74 and IFT81 form a tubulin-binding module
  • together, the IFT81 and IFT74 N-termini are crucial for flagellar assembly, and are likely to function as the main module for IFT of tubulin
  • importance of IFT81 in the skeleton, and role in the anterograde transport complex
  • involved in the bidirectional transport of ciliary proteins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , reproduction/sex
    text
  • spermatogenesis
  • cell differentiation
  • PATHWAY
    metabolism
    signaling
    a component
  • core component of the IFT-B complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IFT81 and IFT74/72 directly interact to form a higher order oligomer consistent with a tetrameric complex
  • IFT52 binds directly to four other IFT-B subunits, IFT81/74/27/HSPB11
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in nephronophthisis and polydactyly
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate gene for nonsyndromic retinal dystrophy
    Marker
    Therapy target
    ANIMAL & CELL MODELS