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FLASH GENE
Symbol IFT81 contributors: mct - updated : 29-08-2017
HGNC name intraflagellar transport 81 homolog (Chlamydomonas)
HGNC id 14313
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a calponin-homology domain within the IFT81 N-terminus and the highly basic N-terminus of IFT74 form a module for IFT of tubulin (
  • a putative signal peptide
  • four coiled-coil domains
  • HOMOLOGY
    interspecies homolog to murine Ift81 (92.9pc)
    homolog to rattus Cdv1 (92.7pc)
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text expression level is increased with testis development
    basic FUNCTION
  • may play an important role in sperm maturation
  • tubulin binding by IFT81 was required for ciliogenesis
  • two core IFT proteins IFT74 and IFT81 form a tubulin-binding module
  • together, the IFT81 and IFT74 N-termini are crucial for flagellar assembly, and are likely to function as the main module for IFT of tubulin
  • importance of IFT81 in the skeleton, and role in the anterograde transport complex
  • involved in the bidirectional transport of ciliary proteins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , reproduction/sex
    text
  • spermatogenesis
  • cell differentiation
  • PATHWAY
    metabolism
    signaling
    a component
  • core component of the IFT-B complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IFT81 and IFT74/72 directly interact to form a higher order oligomer consistent with a tetrameric complex
  • IFT52 binds directly to four other IFT-B subunits, IFT81/74/27/HSPB11
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in nephronophthisis and polydactyly
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate gene for nonsyndromic retinal dystrophy
    Marker
    Therapy target
    ANIMAL & CELL MODELS