Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

RRM2

contributors: mct - updated : 13-07-2017

HGNC name	ribonucleotide reductase M2 polypeptide
HGNC id	10452

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   associated with poor prognosis of gastric cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive stomach RRM2 is a novel target for effective diagnosis and treatment of gastric cancer cancer skin   inhibition of RRM2 converts the transient response of melanoma cells to BRAF inhibitor to a stable response and may be a novel combinatorial strategy to prolong therapeutic response of melanoma patients cancer reproductive uterus inhibition of RRM2 activity may be a novel therapeutic strategy for human cervical cancer cancer digestive colon novel therapeutic target, thus highlighting the potential utility of RRM2 inhibitors in colorectal cancer with oncogenic KRAS

ANIMAL & CELL MODELS