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FLASH GENE
Symbol RRM2 contributors: mct - updated : 13-07-2016
HGNC name ribonucleotide reductase M2 polypeptide
HGNC id 10452
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
associated with poor prognosis of gastric cancer
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerdigestivestomach
RRM2 is a novel target for effective diagnosis and treatment of gastric cancer
cancerskin 
inhibition of RRM2 converts the transient response of melanoma cells to BRAF inhibitor to a stable response and may be a novel combinatorial strategy to prolong therapeutic response of melanoma patients
cancerreproductiveuterus
inhibition of RRM2 activity may be a novel therapeutic strategy for human cervical cancer
cancerdigestivecolon
novel therapeutic target, thus highlighting the potential utility of RRM2 inhibitors in colorectal cancer with oncogenic KRAS
ANIMAL & CELL MODELS