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FLASH GENE
Symbol RRM2 contributors: mct - updated : 13-07-2016
HGNC name ribonucleotide reductase M2 polypeptide
HGNC id 10452
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 3452 - 449 - 2001 11978970
10 - 3284 - 389 - 2001 11978970
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus   highly
Digestiveintestinelarge intestinecolon highly
 intestinesmall intestine  highly
 liver   lowly
 stomach    
Lymphoid/Immunelymph node    
 spleen    
Reproductivemale systemtestis  highly
Respiratorylung   lowly
cell lineage
cell lines
fluid/secretion
at STAGE
cell cycle     cell cycle, S
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Cyclin F-binding motif, in a region of RRM2 located between amino acids 40-65, containing two putative CY motifs
  • HOMOLOGY
    interspecies homolog to murine Rrm2
    Homologene
    FAMILY ribonucleoside diphosphate reductase small chain family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text
  • is largely cytoplasmic
  • its expression is S phase-specific and required for DNA replication
  • basic FUNCTION
  • ribonucleoside diphosphate reductase activity
  • promoter responsible for cell-cycle specific expression
  • plays an active role in tumor progression
  • its activity is a prosurvival function inactivated by proteolysis during apoptosis
  • plays a significant role in the regulation of cell invasiveness, cell migration and tumor metastasis
  • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    pyrimidine biosynthetic pathway
    a component component of the ribonucleotide reductase
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    binding two iron ions
    protein
  • heterodimerizing with RRM1
  • positive role of RRM2 in tumor angiogenesis and growth through regulation of the expression of THBS1 and VEGFA
  • is a new interactor of the F-box protein CCNF
  • Cyclin F directly controls the ubiquitin-mediated degradation of RRM2
  • RRM2 regulates BCL2 protein stability, with RRM2 suppression leading to increased BCL2 degradation, and critical link between RRM2 and BCL2 in apoptosis signaling
  • E2F1 can promote colorectal cancer proliferation, migration, invasion and metastasis by regulating RRM2 transactivation
  • cell & other
    REGULATION
    Other regulated in a cell cycle dependent manner
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    associated with poor prognosis of gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    RRM2 is a novel target for effective diagnosis and treatment of gastric cancer
    cancerskin 
    inhibition of RRM2 converts the transient response of melanoma cells to BRAF inhibitor to a stable response and may be a novel combinatorial strategy to prolong therapeutic response of melanoma patients
    cancerreproductiveuterus
    inhibition of RRM2 activity may be a novel therapeutic strategy for human cervical cancer
    cancerdigestivecolon
    novel therapeutic target, thus highlighting the potential utility of RRM2 inhibitors in colorectal cancer with oncogenic KRAS
    ANIMAL & CELL MODELS