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FLASH GENE

Symbol

ODC1

contributors: mct - updated : 27-05-2015

HGNC name	ornithine decarboxylase 1
HGNC id	8109

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002539 12 - 2062 - 461 - 1990 2318872

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly Lymphoid/Immune tonsils       highly Nervous nerve       highly Reproductive male system prostate     highly Respiratory respiratory tract larynx     highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

cell cycle

cell cycle, G1S, G2M

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , dimer

HOMOLOGY

Homologene

FAMILY

ORN/LYS/ARG decarboxylase class-II family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
text	mainly present in the cytosol

basic FUNCTION	rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine
	has no intrinsic arginine decarboxylase activity
	having an antiapoptotic role for ornithine decarboxylase during oocyte maturation
	dimeric enzyme involved in polyamine biosynthesis, and it catalyzes the decarboxylation of ornithine to putrescin
	regulates the activity and localization of RHOA via polyamination
	ODC1, OAZ1 and AZIN1 play a key role in regulation of intracellular polyamine levels by forming a regulatory circuit through their interactions
	modifier of APC-dependent tumourigenesis
	promotes myoblast proliferation and delays differentiation
	both AMD1 and ODC1 are essential regulators of ESCs and function to ensure high polyamine levels to promote ESC self-renewal

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

polyamine biosynthesis pathway

a component

INTERACTION

DNA

RNA

small molecule	cofactor,
	pyridoxal phosphate

protein	OAZ1 is a positive regulator of ODC1, is homologous to ODC1, exists predominantly as a monomer and lacks decarboxylase activity
	SPR is a novel regulator of ODC1 enzyme activity and, potentially SPR drives ODC1-mediated malignant progression in neuroblastoma

cell & other

REGULATION

activated by

androgens acting via the AR to up-regulate ODC1 in skeletal muscle myoblasts

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       gain of function in pancreatic adenocarcinoma and neuroendocrine tumors constitutional     --over   in dilated cardiomyopathy tumoral     --over   increase of ODC1 mRNA expression during carcinogenesis seems to have a favorable prognostic effect in non-small-cell lung cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS