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FLASH GENE
Symbol ODC1 contributors: mct - updated : 27-05-2011
HGNC name ornithine decarboxylase 1
HGNC id 8109
DNA
TYPE functioning gene
STRUCTURE 7.95 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
LOC391350 2 similar to ENSANGP00000014942 ID2 2p25 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein KIDINS220 2p24 likely homolog of rat kinase D-interacting substance of 220 kDa LOC129642 2p25.2 hypothetical protein BC016005 DDEF2 2p24 development and differentiation enhancing factor 2 ITGB1BP1 2p25.2 integrin beta 1 binding protein 1 CPSF3 2pter-p25 cleavage and polyadenylation specific factor 3, 73kDa LOC285148 2p25.2 hypothetical protein LOC285148 ADAM17 2p25 a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) YWHAQ 2p25 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide TAF1B 2p25 TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa TFCP2L2 2p25.1 transcription factor CP2-like 2 TIEG2 2p25 TGFB inducible early growth response 2 RRM2 2p24 ribonucleotide reductase M2 polypeptide FLJ25102 2p25.1 hypothetical protein FLJ25102 HPCAL1 2p25.1 hippocalcin-like 1 ODC1 2p25 ornithine decarboxylase 1 LOC130063 2p25.1 hypothetical gene LOC130063 FLJ14075 2p25.1 hypothetical protein FLJ14075 ATP6V1C2 2p25.1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C isoform 2 P5 2p25.1 protein disulfide isomerase-related protein LOC388924 2 LOC388924 KCNF1 2p25 potassium voltage-gated channel, subfamily F, member 1 FLJ33534 2p25.1 hypothetical protein FLJ33534 LOC391351 2 similar to RPL6 protein FLJ25143 2p25.1 hypothetical protein FLJ25143 MGC33602 ROCK2 2p24 Rho-associated, coiled-coil containing protein kinase 2 LOC391352 2 similar to peptidyl-Pro cis trans isomerase E2F6 22q11.2 E2F transcription factor 6 GREB1 2p25.1 E2F transcription factor 6 NTSR2 2p25.1 neurotensin receptor 2 LPIN1 2p25.1 lipin 1 FAM10A3 2p25.1 family with sequence similarity 10, member A3 LOC151261 2p25.1 hypothetical LOC151261 TRB2 2p25.1 tribbles homolog 2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2062 - 461 - 1990 2318872
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Lymphoid/Immunetonsils   highly
Nervousnerve   highly
Reproductivemale systemprostate  highly
Respiratoryrespiratory tractlarynx  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period
cell cycle     cell cycle, G1S, G2M
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
Homologene
FAMILY ORN/LYS/ARG decarboxylase class-II family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
text
  • mainly present in the cytosol
  • basic FUNCTION
  • rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine
  • has no intrinsic arginine decarboxylase activity
  • having an antiapoptotic role for ornithine decarboxylase during oocyte maturation
  • dimeric enzyme involved in polyamine biosynthesis, and it catalyzes the decarboxylation of ornithine to putrescin
  • regulates the activity and localization of RHOA via polyamination
  • ODC1, OAZ1 and AZIN1 play a key role in regulation of intracellular polyamine levels by forming a regulatory circuit through their interactions
  • modifier of APC-dependent tumourigenesis
  • promotes myoblast proliferation and delays differentiation
  • both AMD1 and ODC1 are essential regulators of ESCs and function to ensure high polyamine levels to promote ESC self-renewal
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    polyamine biosynthesis pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    pyridoxal phosphate
    protein OAZ1 is a positive regulator of ODC1, is homologous to ODC1, exists predominantly as a monomer and lacks decarboxylase activity
    cell & other
    REGULATION
    activated by androgens acting via the AR to up-regulate ODC1 in skeletal muscle myoblasts
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in pancreatic adenocarcinoma and neuroendocrine tumors
    constitutional     --over  
    in dilated cardiomyopathy
    tumoral     --over  
    increase of ODC1 mRNA expression during carcinogenesis seems to have a favorable prognostic effect in non-small-cell lung cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS