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FLASH GENE
Symbol ODC1 contributors: mct - updated : 27-05-2011
HGNC name ornithine decarboxylase 1
HGNC id 8109
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Lymphoid/Immunetonsils   highly
Nervousnerve   highly
Reproductivemale systemprostate  highly
Respiratoryrespiratory tractlarynx  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period
cell cycle     cell cycle, G1S, G2M
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
Homologene
FAMILY ORN/LYS/ARG decarboxylase class-II family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
text
  • mainly present in the cytosol
  • basic FUNCTION
  • rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine
  • has no intrinsic arginine decarboxylase activity
  • having an antiapoptotic role for ornithine decarboxylase during oocyte maturation
  • dimeric enzyme involved in polyamine biosynthesis, and it catalyzes the decarboxylation of ornithine to putrescin
  • regulates the activity and localization of RHOA via polyamination
  • ODC1, OAZ1 and AZIN1 play a key role in regulation of intracellular polyamine levels by forming a regulatory circuit through their interactions
  • modifier of APC-dependent tumourigenesis
  • promotes myoblast proliferation and delays differentiation
  • both AMD1 and ODC1 are essential regulators of ESCs and function to ensure high polyamine levels to promote ESC self-renewal
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    polyamine biosynthesis pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    pyridoxal phosphate
    protein OAZ1 is a positive regulator of ODC1, is homologous to ODC1, exists predominantly as a monomer and lacks decarboxylase activity
    cell & other
    REGULATION
    activated by androgens acting via the AR to up-regulate ODC1 in skeletal muscle myoblasts
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in pancreatic adenocarcinoma and neuroendocrine tumors
    constitutional     --over  
    in dilated cardiomyopathy
    tumoral     --over  
    increase of ODC1 mRNA expression during carcinogenesis seems to have a favorable prognostic effect in non-small-cell lung cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS