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FLASH GENE

Symbol

MX1

contributors: mct - updated : 14-10-2009

HGNC name	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
HGNC id	7532

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	38.62 kb     17 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

Map	see ETS2 , TFF1

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001144925 17 - 3409 NP_001138397 - 662 - 2009 19297326 NM_002462 17 - 2983 NP_002453 - 662 - 2009 19297326

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       highly   thymus       highly Cardiovascular heart         Endocrine pancreas         Nervous brain         Reproductive male system prostate       Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a tripartite GTP-binding domain consisting of GxxxxGKS, DxxG and TKxD

HOMOLOGY

interspecies	ortholog to murine Mx2
	ortholog to rattus mx2

intraspecies

homolog to MX2

Homologene

FAMILY	dynamin family
	family of large GTPases

CATEGORY

immunity/defense , regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	GTPase
	induction of apoptosis
	regulatory protein involved in Ca2+ signaling
	showing activity against influenza virus and vesicular stomatitis virus (VSV) a rhabdovirus
	recognizes the viral nucleocapsid protein and interferes with its role in viral genome replication
	having certain characteristics of the stress proteins
	inhibits tumor cell motility and invasion
	MX1 and MX2 are intracellular proteins that are induced exclusively by type I IFNs

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

signal transduction

a component

self-assemble into homo-oligomers in vitro

INTERACTION

DNA

RNA

small molecule	metal binding, nucleotide,
	GTP
	mg2+

protein	binding to elements of the cytoskeleton, such as actin and tubulins
	interacts with the second ankyrin-like repeat domain of TRPC6 and interacted with TRPC1, -3, -4, -5, and -7 (regulated the activity of TRPC6 by a mechanism requiring GTP binding)

cell & other

REGULATION

induced by	interferons (alpha and beta at least)
		by small molecules

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in end-stage dilated cardiomyopathy tumoral     --low   by hypermethylation in head and neck tumors constitutional     --other   in multiple sclerosis, MX1 and MX2 proteins are detectable in plaques suggesting endogenous synthesis of type I IFNs as part of the acute inflammatory process

Susceptibility

susceptibility factor for alopecia areata

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer metastases   its expression can be induced by small molecules, potentially offering a new approach to the prevention and treatment of metastasis

ANIMAL & CELL MODELS