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FLASH GENE

Symbol

REN

contributors: mct/npt - updated : 02-09-2008

HGNC name	renin
HGNC id	9958

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	RTD4 renal tubular dysgenesis 4 UAKD2 uromodulin-associated kidney disease 2
Location	1q32.1      Physical location : 204.123.943 - 204.135.465
Synonym name	angiotensinogenase
	angiotensin-forming enzyme
	renin precursor, renal
Synonym symbol(s)	FLJ10761
EC.number	3.4.23.15

DNA

TYPE	functioning gene
STRUCTURE	11.52 kb     10 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
text structure	enhancer 11 kb upstream of its gene that is critical for renin gene expression and physiological sequelae, including response to alteration in salt intake

MAPPING

cloned

Y

linked

Y

status

confirmed

Map	cen - D1S53 - D1S52 ,REN - D1S54 - D1S70 - qter

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000537 10 - 1461 NP_000528 - 406 - Feldt (2008)

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine         Urinary bladder           kidney nephron renal capsule glomerulus

cells

System Cell Pubmed Species Stage Rna symbol Urinary mesenchymal cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

peptidase A1 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
text	secreted

basic FUNCTION	aspartic endopeptidase, angiotensin-forming enzyme, converting angiotensinogen to angiotensin I
	catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure
	primary function of renin is the hydrolytic cleavage of angiotensinogen to angiotensin, with the subsequent stimulation of aldosterone production (Zivna 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with PCBP1, ELAVL1, and HADHB

cell & other

REGULATION

induced by

low blood pressure and hypoxia

ASSOCIATED DISORDERS

corresponding disease(s)

RTD4 , UAKD2

Susceptibility

to arterial hypertension

Variant & Polymorphism other	polymorphisms in the kidney enhancer associated with arterial hypertension

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS