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FLASH GENE
Symbol SMOC2 contributors: shn/pgu - updated : 17-01-2010
HGNC name SPARC related modular calcium binding 2
HGNC id 20323
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Kazal domain
  • two thyroglobulin-like (TY) domains
  • an follistatin (FS) domain
  • a putative signal peptide
  • C-terminal region including two two EF-hand calcium-binding domains
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to Smoc2, Mus musculus
    ortholog to smoc2, Danio rerio
    ortholog to Smoc2, Rattus norvegicus
    ortholog to SMOC2, Pan troglodytes
    Homologene
    FAMILY
  • matricellular proteins of SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40)
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    text matricellular protein
    basic FUNCTION
  • might be involved in the progression of atherosclerosis in aorta
  • angiogenic factor that can modulate angiogenic growth factor activity and angiogenesis
  • potentiates responses to mitogenic and angiogenic factors including FGF and VEGF
  • might associated with pulmonary function by playing an important role in the determination of FEV (ETS oncogene family) and FVC
  • promotes keratinocyte attachment and migration and acts as a regulator of cell-matrix interactions
  • a role for Smoc-2 in growth control, activation of Integrin-Linked Kinase (ILK) and cyclin D1 expression
  • a role in cell cycle by maintaining ILK activity during G1 and involved in mediating the mitogenic and angiogenic
  • effects of growth factors such as VEGF, PDGF, and FGF
  • exhibits pro-angiogenic properties and stimulates cell cycle progression via integrin-linked kinase
  • a novel transcriptional target of activated Aryl-hydrocarbon receptor (Ahr), has a possible role in embryonic gonad development
  • with SMOC1 are matricellular proteins thought to influence growth factor signaling, migration, proliferation, and angiogenesis
  • may mediate intercellular signaling and cell type-specific differentiation during gonad and reproductive tract development
  • regulate interactions between cells and the extracellular matrix
  • potential role in linking the extracellular matrix with the intracellular effector ILK
  • particularly important for dental development but does not play a major role in eye and limb development
  • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+ binding
  • protein
  • interact with integrins and contributes to cell-cycle progression by maintaining integrin-linked kinase (ILK) activity during the G1 phase of the cell cycle
  • connection between the hyper-activation of the small GTPase RAN and the matricellular protein SMOC2 that has important consequences for oncogenic transformation
  • cell & other
    REGULATION
    repressed by Aryl-hydrocarbon receptor in vitro and in vivo
    Other calcium-dependent conformation
    ASSOCIATED DISORDERS
    corresponding disease(s) OLD2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS