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FLASH GENE
Symbol HPCAL4 contributors: mct - updated : 06-12-2013
HGNC name hippocalcin like 4
HGNC id 18212
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal domain, including its myristoylation site, the central alpha-helix, and the C-terminal lobe containing EF-hands 3 and 4 of HPCAL4 are sufficient to transfer its regulatory properties to Calmodulon
    • HOMOLOGY
    interspecies homolog to rattus Nvjp2
    intraspecies homolog to HPCA and HPCAL1
    Homologene
    FAMILY EF-hand superfamily
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may be involved in the calcium-dependent regulation of rhodopsin phosphorylation
  • is a calmodulin -related Ca2+-binding protein, and a neuronal calcium sensor protein
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , nervous system
    text central nervous system development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Ca2+ binding
    protein
  • differential regulation of CACNA1A channels by Calmodulin, HPCAL4, CABP1, and other neurospecific Ca2+-binding proteins is a potentially important determinant of Ca2+ entry in neurotransmission
  • NRF1 could be a regulatory factor for VSNL1 gene expression and for other visinin-like subfamily members including HPCAL4, HPCAL1, HPCA, and NCALD
  • inhibits inactivation and enhances facilitation of CACNA1A channels
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS