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FLASH GENE
Symbol HPCAL4 contributors: mct - updated : 06-12-2013
HGNC name hippocalcin like 4
HGNC id 18212
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainhindbraincerebellum highly
 brainhindbraincerebellumcerebellar cortexhighly
 brainbasal nucleicaudate nucleus   Homo sapiens
 brainbasal nucleiputamen   Homo sapiens
 brainforebraincerebral cortex   Homo sapiens
 brainlimbic systemhippocampus   Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal domain, including its myristoylation site, the central alpha-helix, and the C-terminal lobe containing EF-hands 3 and 4 of HPCAL4 are sufficient to transfer its regulatory properties to Calmodulon
  • HOMOLOGY
    interspecies homolog to rattus Nvjp2
    intraspecies homolog to HPCA and HPCAL1
    Homologene
    FAMILY EF-hand superfamily
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may be involved in the calcium-dependent regulation of rhodopsin phosphorylation
  • is a calmodulin -related Ca2+-binding protein, and a neuronal calcium sensor protein
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , nervous system
    text central nervous system development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Ca2+ binding
    protein
  • differential regulation of CACNA1A channels by Calmodulin, HPCAL4, CABP1, and other neurospecific Ca2+-binding proteins is a potentially important determinant of Ca2+ entry in neurotransmission
  • NRF1 could be a regulatory factor for VSNL1 gene expression and for other visinin-like subfamily members including HPCAL4, HPCAL1, HPCA, and NCALD
  • inhibits inactivation and enhances facilitation of CACNA1A channels
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS