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FLASH GENE
Symbol HPCAL4 contributors: mct - updated : 06-12-2013
HGNC name hippocalcin like 4
HGNC id 18212
DNA
TYPE functioning gene
STRUCTURE 13.06 kb     4 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
RRAGC 1p34 Ras-related GTP binding C MYCBP 1p33-p32.2 c-myc binding protein GJA10 1p35-p34 gap junction protein, alpha 10, 59kDa RHBDL2 1p35.1 rhomboid, veinlet-like 2 (Drosophila) FLJ12666 1p34.2 hypothetical protein FLJ12666 NDUFS5 1p34.2-p33 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) MACF1 1p32-p31 microtubule-actin crosslinking factor 1 BMP8A 1p34.2 bone morphogenetic protein 8a OXCT2P 1p34.2 3-oxoacid CoA transferase 2 pseudogene FLJ14351 1p34.2 hypothetical protein FLJ14351 PABPC4 1p36-p32 poly(A) binding protein, cytoplasmic 4 (inducible form) HEYL 1p34.3 hairy/enhancer-of-split related with YRPW motif-like NT5C1A 1p34.3-p33 5'-nucleotidase, cytosolic IA HPCAL4 1p34.2 hippocalcin like 4 PPIE 1p32 peptidylprolyl isomerase E (cyclophilin E) BMP8B 1p35-p32 bone morphogenetic protein 8 b(osteogenic protein 2) OXCT2 1p34 3-oxoacid CoA transferase 2 IPT 1p35.3-p34.1 3-oxoacid CoA transferase 2 MYCL1 1p34.2 v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) FLJ14490 1p34.2 hypothetical protein FLJ14490 CAP1 1p34.2 CAP, adenylate cyclase-associated protein 1 (yeast) PPT1 1p32 palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile) RLF 1p32 rearranged L-myc fusion sequence LOC127391 1p34.2 similar to dJ39G22.2 (novel protein) ZMPSTE24 1p34.1-p33 zinc metalloproteinase (STE24 homolog, yeast) COL9A2 1p33-p32.3 collagen, type IX, alpha 2 LOC388621 1 similar to 60S ribosomal protein L21 LOC391028 1 similar to Csa-19 LOC64744 1p35.3-p34.1 hypothetical protein AL133206 LOC65243 1p34.2 hypothetical protein LOC65243 FLJ16030 1p34.2 FLJ16030 protein FLJ21144 1p34.2 hypothetical protein FLJ21144
RNA
TRANSCRIPTS type messenger
text transcript has multiple polyadenylation sites
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 4277 - 191 - 1998 10520747
- - 4454 - 119 - 1998 10520747
- - 4776 - 191 - 1998 10520747
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainhindbraincerebellum highly
 brainhindbraincerebellumcerebellar cortexhighly
 brainbasal nucleicaudate nucleus   Homo sapiens
 brainbasal nucleiputamen   Homo sapiens
 brainforebraincerebral cortex   Homo sapiens
 brainlimbic systemhippocampus   Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal domain, including its myristoylation site, the central alpha-helix, and the C-terminal lobe containing EF-hands 3 and 4 of HPCAL4 are sufficient to transfer its regulatory properties to Calmodulon
  • HOMOLOGY
    interspecies homolog to rattus Nvjp2
    intraspecies homolog to HPCA and HPCAL1
    Homologene
    FAMILY EF-hand superfamily
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may be involved in the calcium-dependent regulation of rhodopsin phosphorylation
  • is a calmodulin -related Ca2+-binding protein, and a neuronal calcium sensor protein
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , nervous system
    text central nervous system development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Ca2+ binding
    protein
  • differential regulation of CACNA1A channels by Calmodulin, HPCAL4, CABP1, and other neurospecific Ca2+-binding proteins is a potentially important determinant of Ca2+ entry in neurotransmission
  • NRF1 could be a regulatory factor for VSNL1 gene expression and for other visinin-like subfamily members including HPCAL4, HPCAL1, HPCA, and NCALD
  • inhibits inactivation and enhances facilitation of CACNA1A channels
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS