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FLASH GENE

Symbol

HPCAL4

contributors: mct - updated : 06-12-2013

HGNC name	hippocalcin like 4
HGNC id	18212

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p34.2      Physical location : 40.144.651 - 40.157.089
Synonym name	neural visinin-like Ca2+-binding protein type 2
	neural visinin-like protein 2
	visinin-like protein 2
Synonym symbol(s)	HLP4, DKFZp761G122, NVL-2, VILIP-2

DNA

TYPE	functioning gene
STRUCTURE	13.06 kb     4 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	transcript has multiple polyadenylation sites

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_016257 4 - 4277 NP_057341 - 191 - 1998 10520747 NM_001282397 - - 4454 NP_001269326 - 119 - 1998 10520747 NM_001282396 - - 4776 NP_001269325 - 191 - 1998 10520747

EXPRESSION

Type

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain hindbrain cerebellum   highly   brain hindbrain cerebellum cerebellar cortex highly   brain basal nuclei caudate nucleus     Homo sapiens   brain basal nuclei putamen     Homo sapiens   brain forebrain cerebral cortex     Homo sapiens   brain limbic system hippocampus     Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

N-terminal domain, including its myristoylation site, the central alpha-helix, and the C-terminal lobe containing EF-hands 3 and 4 of HPCAL4 are sufficient to transfer its regulatory properties to Calmodulon

HOMOLOGY

interspecies

homolog to rattus Nvjp2

intraspecies

homolog to HPCA and HPCAL1

Homologene

FAMILY

EF-hand superfamily

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION

basic FUNCTION	may be involved in the calcium-dependent regulation of rhodopsin phosphorylation
	is a calmodulin -related Ca2+-binding protein, and a neuronal calcium sensor protein

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development , nervous system

text	central nervous system development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+ binding

protein	differential regulation of CACNA1A channels by Calmodulin, HPCAL4, CABP1, and other neurospecific Ca2+-binding proteins is a potentially important determinant of Ca2+ entry in neurotransmission
	NRF1 could be a regulatory factor for VSNL1 gene expression and for other visinin-like subfamily members including HPCAL4, HPCAL1, HPCA, and NCALD
	inhibits inactivation and enhances facilitation of CACNA1A channels

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS