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FLASH GENE

Symbol

NETO1

contributors: mct - updated : 20-12-2014

HGNC name	neuropilin (NRP) and tolloid (TLL)-like 1
HGNC id	13823

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	126.02 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_138966 12 - 2513 NP_620416 60.2 533 - 2003 12810072 identical to isoform 2 NM_138999 - - 1849 NP_620552 - 156 soluble isoform 2003 12810072 contains only one CUB domain and lacks the LDLa repeat, the predicted transmembrane domain, and the FXNPXY-like motif NM_153181 11 - 2328 NP_694821 - 532 - 2003 12810072 identical to isoform 3

EXPRESSION

Rna function	mRNAs were observed restrictively in brain throughout embryonic and postnatal stages, uniquely in the pontine nucleus and subplate, which are required for establishing the neuronal circuit formation
Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain diencephalon hypothalamus     Homo sapiens   brain limbic system hippocampus     Homo sapiens Visual eye retina

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain
	a transmembrane domain
	an intracellular FXNPXY-like motif, which has been shown in other proteins to be essential for the internalization of clathrin coated pits during endocytosis

isoforms

Precursor

HOMOLOGY

interspecies

homolog to murine Neto1

Homologene

FAMILY

CATEGORY

signaling

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane

basic FUNCTION	may be involved in intracellular signaling pathway
	having roles during development of the central nervous system
	regulates NMDA receptor-dependent synaptic plasticity and cognition
	have marked effects on receptor properties, increasing further the potential diversity of KAR (Kainate receptor) functional properties
	by regulating kainate receptor excitatory postsynaptic current kinetics, NETO1 can control synaptic temporal summation, spike generation and fidelity
	the ability of NETO1 to regulate both NMDARs and kainate receptors reveals a unique dual role in controlling synaptic transmission by serving as an auxiliary protein for these two classes of ionotropic glutamate receptors in a synapse-specific fashion
	NETO1, and NETO2 are auxiliary subunits that determine key properties of native kainate receptors
	NETO1, and NETO2 transmembrane proteins alter the trafficking, channel kinetics, and pharmacology of the receptors in a subunit-dependent manner
	NETO1 and NETO2 auxiliary subunits coassemble with NMDA receptors (NMDARs) and kainate receptors (KARs) to modulate their function

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDARs in the postsynaptic density
	component of APP/NMDAR trafficking complexes

INTERACTION

DNA

RNA

small molecule

protein

in neurons, kainate receptors can associate with the auxiliary subunits NETO1 or NETO2

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to autism

Variant & Polymorphism other	region of hemizygosity including TCF4, NETO1, and FBXO15 significantly more likely to exhibit autistic-like behaviors

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

deficits in LTP, learning, and memory in Neto1-null mice were rescued by the ampakine CX546 at doses without effect in wild-type